Systemic DNA damage responses: organismal adaptations to genome instability
نویسندگان
چکیده
منابع مشابه
Collateral genome instability by DNA damage in mitosis.
SUMMARY Chromosome segregation errors and DNA damage are in a vicious cycle in cancer cells. Bakhoum and colleagues show that the molecular response to damaged DNA during mitosis impairs the chromosome segregation machinery, adding a new level to the already dangerous relations between different kinds of genomic instability.
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The importance of bystander effects is becoming more appreciated, as studies show they may affect the course of cancer and other chronic diseases. The term "bystander effects" refers to changes in naïve cells sharing the same milieu with cells that have been damaged. Bystander cells may be in contact with, or distant from, damaged cells. In addition, it has been shown in culture that not only p...
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ژورنال
عنوان ژورنال: Trends in Genetics
سال: 2014
ISSN: 0168-9525
DOI: 10.1016/j.tig.2013.12.001